N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide → HCID 67281856, compound

HRID 1368459Notes

Reaction equation

HRID 1368459 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:17]=[C:16]3[C:12]([CH2:13][C:14](=[O:18])[NH:15]3)=[CH:11][CH:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:19]([N:21]([CH2:36][CH3:37])[CH2:22][CH2:23][NH:24][C:25]([C:27]1[C:31]([CH3:32])=[C:30]([CH:33]=O)[NH:29][C:28]=1[CH3:35])=[O:26])[CH3:20]>>[CH2:36]([N:21]([CH2:19][CH3:20])[CH2:22][CH2:23][NH:24][C:25]([C:27]1[C:31]([CH3:32])=[C:30]([CH:33]=[C:13]2[C:12]3[C:16](=[CH:17][C:9]([C:4]4[CH:3]=[C:2]([Cl:1])[CH:7]=[C:6]([Cl:8])[CH:5]=4)=[CH:10][CH:11]=3)[NH:15][C:14]2=[O:18])[NH:29][C:28]=1[CH3:35])=[O:26])[CH3:37]

Participants

3

Reactant 2

HCID 20761785N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamideHCID 21915589HCID 21915589, compound

Product 1

HCID 67281856HCID 67281856, compoundYield 44.6%

Procedure

6-(3,5-Dichlorophenyl)-1,3-dihydroindol-2-one (64 mg, 0.23 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide (60 mg) to give 53 mg (44%) of the title compound as a light brown solid.

Sources & evidence

ORD record
ord-6234d8866dc64dd6bb5fb5606d2fc193
Source dataset
uspto-grants-2003_06
Patent number
US06573293B2

Reaction notes

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