HRID1368474

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20761729

未命名化合物

HCID21915616

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2ccc3c(c2)NC(=O)C3=Cc2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)c(OC)c1

HCID67280888

未命名化合物

收率 31%

PROCEDURE

实验过程

6-(2,4-Dimethoxyphenyl)-1,3-dihydroindol-2-one (51 mg, 0.19 mmol) was condensed with 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-ylethyl)amide (50 mg) to give 30 mg (31%) of the title compound as an orange solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e6a707e7e4704bf0944f0b0a62e6c2db
来源数据集: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06573293B2
来源说明: uspto-grants-2003_06

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=[CH:5][C:4]=1[C:11]1[CH:19]=[C:18]2[C:14]([CH2:15][C:16](=[O:20])[NH:17]2)=[CH:13][CH:12]=1.[N:21]1([CH2:26][CH2:27][NH:28][C:29]([C:31]2[C:35]([CH3:36])=[C:34]([CH:37]=O)[NH:33][C:32]=2[CH3:39])=[O:30])[CH2:25][CH2:24][CH2:23][CH2:22]1>>[N:21]1([CH2:26][CH2:27][NH:28][C:29]([C:31]2[C:35]([CH3:36])=[C:34]([CH:37]=[C:15]3[C:14]4[C:18](=[CH:19][C:11]([C:4]5[CH:5]=[CH:6][C:7]([O:9][CH3:10])=[CH:8][C:3]=5[O:2][CH3:1])=[CH:12][CH:13]=4)[NH:17][C:16]3=[O:20])[NH:33][C:32]=2[CH3:39])=[O:30])[CH2:25][CH2:24][CH2:23][CH2:22]1