4-(2-Hydroxyethyl)indolin-2-one → HCID 67281451, compound

HRID 1368487Notes

Reaction equation

HRID 1368487 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][C:7](=[O:13])[NH:8]2.[CH3:14][C:15]1[C:19]([C:20]([N:22]2[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]2)=[O:21])=[C:18]([CH3:29])[NH:17][C:16]=1[CH:30]=O>>[CH3:14][C:15]1[C:19]([C:20]([N:22]2[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]2)=[O:21])=[C:18]([CH3:29])[NH:17][C:16]=1[CH:30]=[C:6]1[C:5]2[C:9](=[CH:10][CH:11]=[CH:12][C:4]=2[CH2:3][CH2:2][OH:1])[NH:8][C:7]1=[O:13]

Participants

3

Reactant 2

HCID 109430044-(2-Hydroxyethyl)indolin-2-oneHCID 121115823,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde

Product 1

HCID 67281451HCID 67281451, compoundYield 55%

Procedure

4-(2-Hydroxyethyl)-1,3-dihydroindol-2-one (71 mg, 0.4 mmol) was condensed with 3,5-dimethyl-4-(4-methyl-piperazine-1-carbonyl)-1H-pyrrole-2-carbaldehyde to give 90 mg (55%) of the title compound as an orange solid.

Sources & evidence

ORD record
ord-fbcd52509d2a46018262d0fef9e01e08
Source dataset
uspto-grants-2003_06
Patent number
US06573293B2

Reaction notes

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