4-Bromopyridine → HCID 178487488, compound

HRID 1368516Notes

Reaction equation

HRID 1368516 reaction equation
Br[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[CH3:8][O:9][C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([C:20]([C:22]1[N:23]=[CH:24][N:25](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:26]=1)=[O:21])[CH:14]=[CH:13]2>>[NH:25]1[CH:26]=[C:22]([C:20]([C:15]2[CH:14]=[CH:13][C:12]3[C:17](=[CH:18][CH:19]=[C:10]([O:9][CH3:8])[CH:11]=3)[CH:16]=2)([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=2)[OH:21])[N:23]=[CH:24]1

Participants

3

Reactant 2

HCID 142684-BromopyridineHCID 11733735(6-Methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone

Product 1

HCID 178487488HCID 178487488, compound

Procedure

In a similar manner to that described in Example 6-(i), the reaction of 4-bromopyridine (0.92 ml) with (6-methoxynaphthalen-2-yl)-(1-trityl-1H-imidazol-4-yl)ketone (1.0 g) was carried out to give the titled compound (0.88 g) as a colorless solid.

Sources & evidence

ORD record
ord-be519caef0aa438cbf88ac34785976fe
Source dataset
uspto-grants-2003_06
Patent number
US06573289B1

Reaction notes

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