1-Bromopropane → HCID 178458194, compound

HRID 1368538Notes

Reaction equation

HRID 1368538 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([C:17]1[N:18]=[CH:19][N:20](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:21]=1)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:6]=[CH:5]2.Br[CH2:42][CH2:43][CH3:44]>>[NH:20]1[CH:21]=[C:17]([C:12]([C:7]2[CH:6]=[CH:5][C:4]3[C:9](=[CH:10][CH:11]=[C:2]([O:1][CH2:42][CH2:43][CH3:44])[CH:3]=3)[CH:8]=2)([OH:16])[CH:13]([CH3:14])[CH3:15])[N:18]=[CH:19]1

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 220183856-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthol

Product 1

HCID 178458194HCID 178458194, compound

Procedure

In a similar manner to that described in Example 31-(i), the reaction of 1-(6-hydroxynaphthalen-2-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.265 g) with 1-bromopropane (0.24 ml) was carried out to give the titled compound (0.711 g) as a colorless solid.

Sources & evidence

ORD record
ord-69ec8718fa16440e8f99ebc30ddcebba
Source dataset
uspto-grants-2003_06
Patent number
US06573289B1

Reaction notes

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