HCID 532132, compound → HCID 178450066, compound

HRID 1368557Notes

Reaction equation

HRID 1368557 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([C:17]1[N:18]=[CH:19][N:20](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:21]=1)([OH:16])[CH:13]([CH3:15])[CH3:14])[CH:6]=[CH:5]2.[CH3:41][CH:42]([CH3:51])[C:43](N1CCOCC1)=[O:44]>>[OH:16][C:12]([C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:11]=[C:2]([C:43](=[O:44])[CH:42]([CH3:51])[CH3:41])[CH:3]=[CH:4]2)([C:17]1[N:18]=[CH:19][NH:20][CH:21]=1)[CH:13]([CH3:14])[CH3:15]

Participants

3

Reactant 2

HCID 532132HCID 532132, compoundHCID 22018349HCID 22018349, compound

Product 1

HCID 178450066HCID 178450066, compoundYield 84.4%

Procedure

In a similar manner to that described in Example 57-(i), the reaction of 1-(6-bromonaphthalen-2-yl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (2.0 g) with 2-methyl-1-(4-morpholinyl)-1-propanone (688 mg) was carried out to give the titled compound (966 mg) as a colorless powder.

Sources & evidence

ORD record
ord-f58a345d5fb74c3994cd9b6f0d8c9de3
Source dataset
uspto-grants-2003_06
Patent number
US06573289B1

Reaction notes

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