1-Phenylethanol → Acetophenone

Participants

Reaction Conditions

Reaction Steps

The procedure was the same as in Example 11, using diethylzinc (1 mmol) as catalyst and N,N′-bis-(1-(S)-phenylethyl)-1,2-ethylenediamine in a quantity five times less, i.e. 0.2 mmol, as ligand. After the mixture had been stirred at 20° C. for 24 hours, hydrolysis was carried out with a 30% excess of soda, and a mixture of methylphenylcarbinol comprising 88% of the (S) isomer and 12% of the (R) isomer, that is to say, an ee of 74%, was recovered with a yield of 95%.

Provenance & Evidence