Benzylamine → 4-Benzylamino-5-methylsulfonyl-2-methylbenzoic acid

HRID 1368749Notes

Reaction equation

HRID 1368749 reaction equation
ClCl.[CH3:3][C:4]1[CH:12]=[C:11](Cl)[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].[CH2:18]([NH2:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([NH:25][C:11]1[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH3:3])[CH:12]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 24526ChlorineHCID 108244784-chloro-2-methyl-5-(methylsulfonyl)Benzoic acid

Product 1

HCID 107818944-Benzylamino-5-methylsulfonyl-2-methylbenzoic acid

Procedure

in stage c) the chlorine substituent is converted into a benzylamino group by reacting 2-methyl-4-chloro-5-methylsulfonylbenzoic acid with benzylamine to give the corresponding intermediate 4-benzylamino-5-methylsulfonyl-2-methylbenzoic acid,

Sources & evidence

ORD record
ord-3f7dceefc315415fac88f181dd373fc7
Source dataset
uspto-grants-2003_06
Patent number
US06573404B2

Reaction notes

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