Stannous chloride dihydrate → HCID 70012413, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2(S)-hydroxy-3(S)-[3(S)-tetrahydropyranyloxycarbonyl]amino-1-(4-nitrobenzenesulfonyl)-1-isobutylamino-4-phenylbutane (36 mg, 0.067 mmol) and SnCl2.2H2O (77 mg, 0.34 mmol) in 1 mL of EtOAc was heated to 70° C. After 1 h the starting material disappeared and the solution was allowed to cool to room temperature. The mixture was poured into sat aq NaHCO3 solution (3 mL) and extracted with EtOAc (10 mL). The organic extract was dried over anhyd MgSO4 and concentrated under reduced pressure to give 30 mg of 2(S)-hydroxy-3(S)-[3(S)-tetrahydropyranyloxycarbonyl]amino-1-(4-aminobenzenesulfonyl)-1-isobutylamino-4-phenylbutane.

Provenance & Evidence