HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-Ethoxy-2-fluoro-4-(4-(4-pentylcyclohexyl)cyclohexyl)methyloxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Iodomethyl-4-(4-pentylcyclohexyl)cyclohexane | HCID 18517269 | — |
| Reactant | 4-Ethoxy-3-fluorophenol | HCID 18517276 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Ethoxy-2-fluoro-4-(4-(4-pentylcyclohexyl)cyclohexyl)methyloxybenzene | HCID 18517288 | 39% |
Reaction Steps
1-Iodomethyl-4-(4-pentylcyclohexyl)cyclohexane (9.8 g, 26 mmol) was reacted with 4-ethoxy-3-fluorophenol (3.7 g, 24 mmol) in THF (60 ml) in the presence of NaH (ca. 24 mmol) used as a base. After treatment was carried out by the same method as in Example 3 to obtain 1-ethoxy-2-fluoro-4-(4-(4-pentylcyclohexyl)cyclohexyl)methyloxybenzene (yield: 39%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576303B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-6fbb2d0b401240f58ee5338ba8860f50 |
| Source note | uspto-grants-2003_06 |