HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Methyl 2-chloro-3-chlorocarbonyl-4-methylsulfonylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Methyl 2-chloro-3-hydroxycarbonyl-4-methylsulfonylbenzoate | HCID 18517418 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 2-chloro-3-chlorocarbonyl-4-methylsulfonylbenzoate | HCID 18517408 | 94.9% |
Reaction Steps
2 drops of dimethylformamide and 11.9 g (0.1 mol) of thionyl chloride were added to a solution of 6.0 g (0.021 mol) of methyl 2-chloro-3-hydroxycarbonyl-4-methylsulfonylbenzoate and 50 ml of dry toluene. The solution was heated under reflux for 4 hours. After removal of the solvent under reduced pressure, 6.2 g of methyl 2-chloro-3-chlorocarbonyl-4-methylsulfonylbenzoate were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576596B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-dc418e1dc96e465493303c86af10793d |
| Source note | uspto-grants-2003_06 |