反应详情

60 ml of concentrated sulfuric acid were added dropwise to a solution of 424.0 g (2 mol) of 2,4-dichloro-3-methylbenzoic acid and 1500 ml of methanol. After heating for 5 hours under reflux, the reaction mixture was cooled, concentrated under reduced pressure and then taken up in 1000 ml of methylene chloride. The organic phase was washed with water, then with 5% strength of sodium hydrogen carbonate solution and then again with water, dried and concentrated under reduced pressure. 401.0 g of methyl 2,4-dichloro-3-methylbenzoate were obtained.

1. temperatureAfter heating for 5 hours
2. temperatureunder reflux
3. temperaturethe reaction mixture was cooled
4. concentrationconcentrated under reduced pressure
5. washThe organic phase was washed with water
6. dry with materialwith 5% strength of sodium hydrogen carbonate solution and then again with water, dried
7. concentrationconcentrated under reduced pressure