Ethanol → HCID 12056933, compound

HRID 1368845Notes

Reaction equation

HRID 1368845 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][C:12]2[C:13]([NH2:19])=[CH:14][CH:15]=[C:16](C)[CH:17]=2)[N:4]=1.[N:20]#[C:21]Br.O.[CH2:24](O)C>>[NH2:20][C:21]1[N:11]([C:5]2[N:6]=[C:7]([O:9][CH3:10])[CH:8]=[C:3]([O:2][CH3:1])[N:4]=2)[C:12]2[CH:17]=[CH:16][C:15]([CH3:24])=[CH:14][C:13]=2[N:19]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 962WaterHCID 10476Cyanogen BromideHCID 22507055HCID 22507055, compound

Product 1

HCID 12056933HCID 12056933, compound

Conditions

Temperature
60 °C

Procedure

N′-(4,6-dimethoxypyrimidin-2-yl)-4-methylbenzene-1,2-diamine (2.00 g) was dissolved in ethanol, and cyanogen bromide (1.00 g) was added thereto at room temperature, followed by stirring at 60° C. for 1 hour. Water was added, and the crystals were collected by filtration, washed with water and dried to obtain 2.03 g of the desired product as a white powder (m.p. at least 300° C.).

Workup

  1. customat room temperature
  2. filtrationthe crystals were collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-04ff3b2be098405c8b9c3910c4d976dd
Source dataset
uspto-grants-2003_06
Patent number
US06576631B1

Reaction notes

Loading…