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HRID1368857

反应详情

EQUATION

反应方程式

HRID 1368857 的结构方程式

REACTANTS

反应物

4
结构：CN=C=S
HCID11167

Methyl isothiocyanate

C2H3NS

结构：CN=C=O
HCID12228

Methyl isocyanate

C2H3NO

2 次

结构：S=C=NC1CCCC1
HCID141792

Cyclopentyl isothiocyanate

C6H9NS

结构：CNC(=O)NC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)ncnc32)[C@H](O)[C@@H]1O
HCID20592071

未命名化合物

2 次

PRODUCTS

生成物

2
结构：O[C@@H]1[C@H](O)[C@@H](CNC(=S)NC2CCCC2)O[C@H]1n1cnc2c(N[C@@H]3CCOC3)ncnc21
HCID20592023

未命名化合物

结构：CNC(=S)NC[C@H]1O[C@@H](n2cnc3c(N[C@@H]4CCOC4)ncnc32)[C@H](O)[C@@H]1O
HCID20592027

未命名化合物

PROCEDURE

实验过程

Compound 77 was prepared in the manner of compound 24 substituting methyl isothiocyanate for methyl isocyanate and refluxing for 16 h [MS 410.3 (M+1)]. 2-{6-[((3R)oxolan-3-yl)amino]purin-9-yl}(4S,2R,3R,5R)-5-({[(cyclopentylamino)thioxomethyl]amino}methyl)oxolane-3,4-diol (78) Compound 78 was prepared in the manner of compound 24 substituting cyclopentyl isothiocyanate for methyl isocyanate and refluxing for 16 h [MS 464.3 (M+1)].

WORKUP

后处理

  1. temperaturerefluxing for 16 h [MS 410.3 (M+1)]
  2. temperaturerefluxing for 16 h [MS 464.3 (M+1)]