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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1368859Generated: October 26, 2026

Methyl Isocyanate → n-[(5-{6-[((3r)Oxolan-3-yl)amino]purin-9-yl}(3s,2r,4r,5r)-3,4-dihydroxyoxolan-2-yl)methyl](propylamino)carboxamide

https://huagongshe.com/reaction/1368859

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl IsocyanateHCID 12228—
ReactantPropyl isocyanateHCID 61033—
Reactantn-[(5-{6-[((3r)Oxolan-3-yl)amino]purin-9-yl}(3s,2r,4r,5r)-3,4-dihydroxyoxolan-2-yl)methyl](methylamino)carboxamideHCID 20592071—
Productn-[(5-{6-[((3r)Oxolan-3-yl)amino]purin-9-yl}(3s,2r,4r,5r)-3,4-dihydroxyoxolan-2-yl)methyl](propylamino)carboxamideHCID 20592072—

Reaction Steps

Compound 93 was prepared in the manner of compound 24 substituting propyl isocyanate for methyl isocyanate and refluxing for 16 h [MS 422.3 (M+1)].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06576620B2
Source datasetuspto-grants-2003_06
ORD IDord-070a131323cf4905ad1a132946a23288
Source noteuspto-grants-2003_06