4-Methylmorpholine → HCID 18517998, compound

Participants

Reaction Steps

360 mg of methyl 3-(2-aminoacetylamino)-3-(2-nitrophenyl)propionate hydrochloride are dissolved in 35 ml of DMF, and 190 mg of 4-(4-methylpyridin-2-ylamino)butyric acid are added. After cooling the reaction mixture to 0°, 450 mg of TBTU and 63 mg of HOBt are added. It is neutralized with 0.15 ml of N-methylmorpholine and stirred at room temperature overnight. The solvent is distilled off, and the residue is mixed with 30 ml of ethyl acetate and washed with half-concentrated bicarbonate solution and saturated brine and worked up further as usual. Methyl 3-{2-[4-(4-methylpyridin-2-ylamino)butyrylamino]acetylamino}-3-(2-nitrophenyl)propionate is obtained.

Provenance & Evidence