Ethanol → HCID 18518004, compound

HRID 1368913Notes

Reaction equation

HRID 1368913 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:13][C:14](=[O:31])[CH2:15][NH:16][C:17](=[O:30])[CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]2[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][N:24]=2)[CH2:9][C:10]([OH:12])=[O:11])=[CH:4][C:3]=1[N+:32]([O-:34])=[O:33].S(Cl)(Cl)=O.[CH2:39](O)[CH3:40]>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:13][C:14](=[O:31])[CH2:15][NH:16][C:17](=[O:30])[CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]2[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][N:24]=2)[CH2:9][C:10]([O:12][CH2:39][CH3:40])=[O:11])=[CH:4][C:3]=1[N+:32]([O-:34])=[O:33]

Participants

4

Reactant 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 98918133-(4-Chloro-3-nitrophenyl)-3-{2-[5-(4-methylpyridin-2-ylamino)pentanoylamino]acetylamino}propionic acid

Product 1

HCID 18518004HCID 18518004, compound

Procedure

Esterification of 3-(4-chloro-3-nitrophenyl)-3-{2-[5-(4-methylpyridin-2-ylamino)pentanoylamino]acetylamino}propionic acid by activation with thionyl chloride and reaction with ethanol under standard conditions produces ethyl 3-(4-chloro-3-nitrophenyl)-3-{2-[5-(4-methylpyridin-2-ylamino)pentanoylamino]acetylamino}propionate hydrochloride, RT 27.95, FAB-MS (M+H)+ 520.

Sources & evidence

ORD record
ord-4aeefbbdfcfc4b598a142a5a3f6e1314
Source dataset
uspto-grants-2003_06
Patent number
US06576637B1

Reaction notes

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