HuagongsheHuagongshe Chemistry Print Report · For research reference only
Anisole → 2-(4-chlorophenyl)-1-(4-methoxyphenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Anisole | HCID 7519 | — |
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | (4-Chlorophenyl)acetic acid | HCID 15880 | — |
| Product | 2-(4-chlorophenyl)-1-(4-methoxyphenyl)ethanone | HCID 457242 | — |
Reaction Steps
Anisole (13.9 g, 0.13 mol) is added to a stirred solution of 4-chlorophenylacetic acid (20.0 g, 0.12 mol) in trifluoroacetic anhydride (16.5 ml, 0.12 mol). The mixture is stirred in room temperature for 24 h. Ice water is added and the crystallized product is collected on a sinter and washed with water. The product is recrystallized from ethanol. The yield is 20.4 g, 67%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576645B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-91a8c0f7aff24976a3d28fb63d44abc1 |
| Source note | uspto-grants-2003_06 |