Benzyl 4-hydroxyphenyl ketone → 1-{4-[2-(2-Benzyloxyethoxy)ethoxy]phenyl}-2-phenylethanone

HRID 1368950Notes

Reaction equation

HRID 1368950 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:16])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[CH2:17]([O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29]Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH2:17]([O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:16])[CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:6][CH:7]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 75607Benzyl 4-hydroxyphenyl ketoneHCID 48613212-(2-Benzyloxyethoxy)ethyl chloride

Product 1

HCID 225045131-{4-[2-(2-Benzyloxyethoxy)ethoxy]phenyl}-2-phenylethanone

Procedure

is prepared according to example 4c starting from 1-(4-hydroxyphenyl)-2-phenyl ethanone (prepared according examples 4a-b) (10.0 g, 47.1 mmol) and 2-(2-benzyloxyethoxy)ethyl chloride (11.0 g, 51.8 mmol). The product was triturated three times with warm heptane to remove byproducts. Yield 9.6 g, 52%.

Workup

  1. customis prepared
  2. customThe product was triturated three times with warm heptane
  3. customto remove byproducts

Sources & evidence

ORD record
ord-5094ff0e473949d883dcf85af749ab8e
Source dataset
uspto-grants-2003_06
Patent number
US06576645B1

Reaction notes

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