HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-bromo-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-bromo-4H-furo[3,2-b]pyrrole-5-carboxylate | HCID 12733394 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-bromo-4H-furo[3,2-b]pyrrole-5-carboxylic acid | HCID 22556506 | — |
Reaction Steps
2-Bromo-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester (Krutosikova, A.; Kovac, J.; Dandarova, M.; Lesko, J.; Ferik, S., Collect. Czech. Chem. Commun., 46: 2564-2573 (1981)) was hydrolyzed according to Procedure E (4 equiv 2 N NaOH, ethanol; reflux 5h, room temperature overnight; after concentration to remove ethanol, residue partitioned between ethyl acetate and 2 N HCl; combined organic phases dried over Na2SO4; no purification).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576653B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-06de5db702b04305939baa9022d59d2d |
| Source note | uspto-grants-2003_06 |