HCID 22556513, compound → HCID 9799912, compound

HRID 1368977Notes

Reaction equation

HRID 1368977 reaction equation
[C:1]([C:3]1[O:10][C:9]2[CH:8]=[C:7]([C:11]([OH:13])=O)[NH:6][C:5]=2[CH:4]=1)#[N:2].Cl.[NH2:15][C@@H:16]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:17]([N:19]1[CH2:22][CH:21]([OH:23])[CH2:20]1)=[O:18]>>[CH2:24]([C@H:16]([NH:15][C:11]([C:7]1[NH:6][C:5]2[CH:4]=[C:3]([C:1]#[N:2])[O:10][C:9]=2[CH:8]=1)=[O:13])[C:17]([N:19]1[CH2:22][CH:21]([OH:23])[CH2:20]1)=[O:18])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 22556513HCID 22556513, compoundHCID 69687670HCID 69687670, compound

Product 1

HCID 9799912HCID 9799912, compound

Procedure

2-Cyano-4H-furo[3,2-b]pyrrole-5-carboxylic acid and (2S)-amino-1-(3-hydroxy-azetidin-1-yl)-3-phenyl-propan-1-one hydrochloride were coupled according to Procedure B (reaction mixture partitioned between ethyl acetate and water prior to acidic washing).

Workup

  1. customreaction mixture
  2. custompartitioned between ethyl acetate and water
  3. washto acidic washing)

Sources & evidence

ORD record
ord-a42b29f41e1c4c39b7c8dbed63a4bed6
Source dataset
uspto-grants-2003_06
Patent number
US06576653B2

Reaction notes

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