HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acrylate → HCID 67550720, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acrylate | HCID 25188 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Acetic acid, azido-, ethyl ester | HCID 69480 | — |
| Reactant | 1-Hydroxyethyl radical | HCID 119440 | — |
| Reactant | 5-(Methylsulfanyl)thiophene-2-carbaldehyde | HCID 2736997 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 67550720 | HCID 67550720 | — |
Reaction Steps
5-Methylsulfanyl-thiophene-2-carbaldehyde was annulated according to Procedure H (aldehyde and azido-acetic acid ethyl ester added as ethanol solution (1 M of ester) to −20° C. ethoxide solution; allow to warm to 10° C. over 4 h; reaction poured into cold saturated aqueous NH4Cl; after ether extraction, acrylate organic phase washed with water until aqueous phase was neutral; crude acrylate solution heated at reflux for 2 h, allowed to cool to room temperature, stirred overnight).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576653B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-6a8fb53050ad4e6e93b4324c7a15f7b6 |
| Source note | uspto-grants-2003_06 |