Potassium Hydroxide → HCID 18518704, compound

HRID 1369004Notes

Reaction equation

HRID 1369004 reaction equation
C[O:2][C:3]([C:5]1([CH3:17])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[CH2:8][CH2:7][CH2:6]1)=[O:4].[OH-].[K+]>CCO.O>[CH3:16][O:15][C:12]1[CH:13]=[C:14]2[C:9]([CH2:8][CH2:7][CH2:6][C:5]2([C:3]([OH:4])=[O:2])[CH3:17])=[CH:10][CH:11]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 70011850HCID 70011850, compound

Product 1

HCID 18518704HCID 18518704, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 7-methoxy-1-methyltetralin-1-yl-carboxylic acid, methyl ester (0.67 g; 2.9 mmol; from step (ii) above) and KOH (4 g) in EtOH:H20 (1:1; 50 mL) was stirred overnight. The resultant mixture was diluted with water and extracted with ether. The aqueous layer was acidified (HCl) and extracted 3 times with ether. The combined organic layer was washed with water, dried (Na2SO4), and concentrated. Yield 0.58 g (81%).

Workup

  1. extractionextracted with ether
  2. extractionextracted 3 times with ether
  3. washThe combined organic layer was washed with water
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-fceaf1b7220b48bca4b067dc1af64bc6
Source dataset
uspto-grants-2003_06
Patent number
US06576657B2

Reaction notes

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