Methyl iodide → 4-methoxy-2,3-dihydro-1H-inden-1-one

Participants

Reaction Steps

Cs2CO3 (7 g; 21.5 mmol) followed by CH3I (10 g; 70 mmol) was added to a solution of 4-hydroxy-1-indanone (5.0 g; 34 mmol) in THF (30 mL) and the mixture was stirred at RT for 60 h. The reaction mixture was filtered and concentrated, and the crude product was purified using flash chromatography (SiO2; methylene chloride) to yield 3.1 g (56%) of the sub-title substance.

Provenance & Evidence