6-Iodo-4-trifluoromethyl-isatin → HCID 18518539, compound

HRID 1369079Notes

Reaction equation

HRID 1369079 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:11]=[C:10]([I:12])[CH:9]=[C:8]2[C:4]=1[C:5](=[O:14])[C:6](=[O:13])[NH:7]2.[CH:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][C:18]=1[Mg]Br>>[F:16][C:2]([F:15])([F:1])[C:3]1[CH:11]=[C:10]([I:12])[CH:9]=[C:8]2[C:4]=1[C:5]([OH:14])([C:19]1[CH:18]=[CH:17][C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=1)[C:6](=[O:13])[NH:7]2

Participants

3

Reactant 2

HCID 99973896-Iodo-4-trifluoromethyl-isatinHCID 178418423HCID 178418423, compound

Product 1

HCID 18518539HCID 18518539, compoundYield 6.5%

Procedure

The title compound (35.8 mg, 6.5%) was prepared from 4-trifluoromethyl-6-iodoisatin (400 mg, 1.17 mmol) and 2-naphthyl magnesium bromide by the procedure similar to that described in Example 1.

Sources & evidence

ORD record
ord-ee846b2354b34011911900d410fec525
Source dataset
uspto-grants-2003_06
Patent number
US06576656B1

Reaction notes

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