Propargyl alcohol → HCID 18518668, compound

HRID 1369080Notes

Reaction equation

[CH2:1]([N:3]([CH2:33][CH3:34])[CH2:4][CH2:5][CH2:6][O:7][N:8]1[C:16]2[C:11](=[C:12]([C:18]([F:21])([F:20])[F:19])[CH:13]=[C:14](I)[CH:15]=2)[CH:10]([C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=2)[C:9]1=[O:32])[CH3:2].[CH:35]#[C:36][CH2:37][OH:38]>>[CH2:1]([N:3]([CH2:33][CH3:34])[CH2:4][CH2:5][CH2:6][O:7][N:8]1[C:16]2[C:11](=[C:12]([C:18]([F:21])([F:20])[F:19])[CH:13]=[C:14]([C:35]#[C:36][CH2:37][OH:38])[CH:15]=2)[CH:10]([C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=2)[C:9]1=[O:32])[CH3:2]

Participants

Reactant 2

HCID 7859Propargyl alcohol

HCID 18518568HCID 18518568, compound

Product 1

HCID 18518668HCID 18518668, compoundYield 34%

Procedure

The title compound (3.7 mg, 34%) was prepared from 3-diethylaminopropyloxy-4-trifluoromethyl-6-iodo-3-(2-naphthyl)oxindole (12.4 mg, 0.0213 mmol) and 1-propyn-3-ol by the procedure similar to that described in Reference Example 21.

Sources & evidence

ORD record: ord-1eb43568849a49c0b32b3483185d94cf
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06576656B1

Reaction notes

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