HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl propionate → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(2-t-butoxycarbonyl-1-ethynyl)-3-hydroxy-3-(2-naphthyl)oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl propionate | HCID 88561 | — |
| Reactant | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-naphthyl)oxindole | HCID 11827896 | — |
| Product | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(2-t-butoxycarbonyl-1-ethynyl)-3-hydroxy-3-(2-naphthyl)oxindole | HCID 56999258 | — |
Reaction Steps
The title compound (75.7 mg, quant.) was prepared from 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-naphthyl)oxindole of Example 48 (75.1 mg, 0.132 mmol) and t-butyl propionate by the procedure similar to that described in Reference Example 21.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576656B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-e6262199f0314437b2e577a9e3b3b1c1 |
| Source note | uspto-grants-2003_06 |