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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1369091Generated: October 26, 2026

tert-Butyl propionate → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(2-t-butoxycarbonyl-1-ethynyl)-3-hydroxy-3-(2-naphthyl)oxindole

https://huagongshe.com/reaction/1369091

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl propionateHCID 88561—
Reactant1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-naphthyl)oxindoleHCID 11827896—
Product1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(2-t-butoxycarbonyl-1-ethynyl)-3-hydroxy-3-(2-naphthyl)oxindoleHCID 56999258—

Reaction Steps

The title compound (75.7 mg, quant.) was prepared from 1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-naphthyl)oxindole of Example 48 (75.1 mg, 0.132 mmol) and t-butyl propionate by the procedure similar to that described in Reference Example 21.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06576656B1
Source datasetuspto-grants-2003_06
ORD IDord-e6262199f0314437b2e577a9e3b3b1c1
Source noteuspto-grants-2003_06