1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-chlorophenyl)oxindole → (+)-1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-(3-methanesulfonylamino-1-propynyl)-3-hydroxy-3-(2-chlorophenyl)oxindole

Participants

Reaction Steps

The title compound (270 mg) was prepared from (+)-1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-chlorophenyl)oxindole of Example 72(1) (347 mg, 0.628 mmol) and 1-methanesulfonylamino-2-propyne by the procedure similar to that described in Reference Example 21. The hydrochloride of the title compound was obtained by treating with 4 N HCl in dioxane followed by concentration to dryness.

Provenance & Evidence