HRID1369094

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12990216

未命名化合物

HCID54114534

未命名化合物

PRODUCTS

产物

HCID18518604

未命名化合物

PROCEDURE

实验过程

The title compound (740 mg) was prepared from (+)-1-(2-diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-chlorophenyl)oxindole of Example 72(1) (102 mg, 0.185 mmol) and N-hydroxyethyl-4-pentynamide by the procedure similar to that described in Reference Example 21. The hydrochloride of the title compound was obtained by treating with 4 N HCl in dioxane followed by concentration to dryness.

WORKUP

后处理

customThe hydrochloride of the title compound was obtained

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-2a18e61a7d534a278dc7c40881974985
来源数据集: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06576656B1
来源说明: uspto-grants-2003_06

反应SMILES

[CH2:1]([N:3]([CH2:29][CH3:30])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:11]=[C:12](I)[CH:13]=2)[C:8]([OH:27])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[C:7]1=[O:28])[CH3:2].[OH:31][CH2:32][CH2:33][NH:34][C:35](=[O:40])[CH2:36][CH2:37][C:38]#[CH:39]>>[CH2:1]([N:3]([CH2:29][CH3:30])[CH2:4][CH2:5][N:6]1[C:14]2[C:9](=[C:10]([C:16]([F:19])([F:18])[F:17])[CH:11]=[C:12]([C:39]#[C:38][CH2:37][CH2:36][C:35](=[O:40])[NH:34][CH2:33][CH2:32][OH:31])[CH:13]=2)[C:8]([OH:27])([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])[C:7]1=[O:28])[CH3:2]