HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodoisatin → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(phenyl)oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodoisatin | HCID 11026552 | — |
| Reactant | HCID 178418255 | HCID 178418255 | — |
| Product | 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(phenyl)oxindole | HCID 18518612 | 53% |
Reaction Steps
The title compound (53%) was prepared from 1-(2-diethylaminoethyl)-6-iodo-4-trifluoromethylisatin and phenylmagnesium bromide by the procedure similar to that described in Example 1. The compound obtained was further purified by reverse phase HPLC with water-acetonitrile-trifluoroacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576656B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-bcab12cf8bd74b328e0474a446f10f9f |
| Source note | uspto-grants-2003_06 |