1-Methyl-4,6-dichloroisatin → HCID 18518546, compound

HRID 1369123Notes

Reaction equation

HRID 1369123 reaction equation
[CH3:1][N:2]1[C:12]2[C:7](=[C:8]([Cl:14])[CH:9]=[C:10]([Cl:13])[CH:11]=2)[C:5](=[O:6])[C:3]1=[O:4].[CH:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][C:16]=1[Mg]Br>>[CH3:1][N:2]1[C:12]2[C:7](=[C:8]([Cl:14])[CH:9]=[C:10]([Cl:13])[CH:11]=2)[C:5]([C:17]2[CH:16]=[CH:15][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=2)([OH:6])[C:3]1=[O:4]

Participants

3

Reactant 2

HCID 185185371-Methyl-4,6-dichloroisatinHCID 178418423HCID 178418423, compound

Product 1

HCID 18518546HCID 18518546, compoundYield 1.5%

Procedure

The title compound (59.1 mg, 1.5%) was prepared from 1-methyl-4,6-dichloroisatin (250 mg) and 2-naphthyl magnesium bromide by the procedure similar to that described in Example 1.

Sources & evidence

ORD record
ord-c16ce436d4db43338c23f991f135c002
Source dataset
uspto-grants-2003_06
Patent number
US06576656B1

Reaction notes

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