HCID 18518630, compound → HCID 18518560, compound

HRID 1369126Notes

Reaction equation

HRID 1369126 reaction equation
[Si:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:24]2[C:19](=[C:20]([Br:26])[CH:21]=[C:22]([I:25])[CH:23]=2)[C:17](=[O:18])[C:15]1=[O:16])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1[Mg]Br>>[Si:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:24]2[C:19](=[C:20]([Br:26])[CH:21]=[C:22]([I:25])[CH:23]=2)[C:17]([OH:18])([C:29]2[CH:28]=[CH:27][C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:30]=2)[C:15]1=[O:16])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 18518630HCID 18518630, compoundHCID 178418423HCID 178418423, compound

Product 1

HCID 18518560HCID 18518560, compoundYield 75%

Procedure

The title compound (463 mg, 75%) was prepared from 1-(5-t-butyldimethylsilyloxypentyl)-4-bromo-6-iodoisatin (500 mg, 0.923 mmol) and 2-naphthylmagnesium bromide by the procedure similar to that described in Example 1.

Sources & evidence

ORD record
ord-b2c958b5d7eb495ab1496648d7d6befd
Source dataset
uspto-grants-2003_06
Patent number
US06576656B1

Reaction notes

Loading…