Potassium bisulfate → HCID 18518591, compound

Participants

Reaction Steps

To a solution of 1-(5-t-butyldimethylsilyloxypentyl)-4-bromo-6-iodo-3-hydroxy-3-(2-naphthyl)oxindole (450 mg, 0.67 mmol) in THF (5 mL) was added 1 N n-tetrabutylammonium fluoride in THF (1 mL, 1 mmol) and the mixture was stirred for 4 h at room temperature. 5% KHSO4 was added and the mixture was extracted with ethyl acetate. The extracts were dried over MgSO4 and concentrated. The residue was purified by silica gel column chromatography with 1:1 to 0:1 hexane/ethyl acetate to give the title compound (349 mg, 94%).

Provenance & Evidence