Water → HCID 18518659, compound

Participants

Reaction Steps

To a solution of 1-(5-hydroxypentyl)-4-bromo-6-iodo-3-hydroxy-3-(2-naphthyl)oxindole (155 mg, 0.279 mmol) and triethylamine (0.06 mL, 0.43 mmol) in dichloromethane (5 mL) was added methanesulfonyl chloride (0.025 mL, 0.323 mmol) at 0° C. The mixture was stirred for 5 min at the same temperature and water was added. The mixture was extracted with ethyl acetate and the extracts were dried over MgSO4 and concentrated. The residue was purified by silica gel column chromatography with 3:2 hexane/ethyl acetate to give the mixture (116 mg) of the title compound and dimesylate.

Provenance & Evidence