1H-1,2,4-Triazole → HCID 10118775, compound

HRID 1369140Notes

Reaction equation

HRID 1369140 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[CH2:6][N:7]([CH3:24])[C:8](=[O:23])[C:9]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[CH:13][C:12](Cl)=[N:11][CH:10]=1.[NH:34]1[CH:38]=[N:37][CH:36]=[N:35]1>>[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[CH2:6][N:7]([CH3:24])[C:8](=[O:23])[C:9]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[CH3:21])=[CH:13][C:12]([N:34]2[CH:38]=[N:37][CH:36]=[N:35]2)=[N:11][CH:10]=1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 10277890N-(3,5-bis-trifluoromethyl-benzyl)-6-chloro-N-methyl-4-o-tolyl-nicotinamide

Product 1

HCID 10118775HCID 10118775, compoundYield 87.3%

Conditions

Temperature
130 °C

Procedure

A mixture of 1.00 g (2.05 mmol) N-(3,5-bis-trifluoromethyl-benzyl)-6-chloro-N-methyl-4-o-tolyl-nicotinamide and 1.42 g (20.5 mmol) 1,2,4-triazole was stirred at 130° C. for 36 h. After cooling to room temperature the crude mixture was purified by flash chromatography to give 0.93 g (87%) of the title compound as a white solid.

Workup

  1. customwas purified by flash chromatography

Sources & evidence

ORD record
ord-e19a512d0a65466282faf2dcc9c8cb97
Source dataset
uspto-grants-2003_06
Patent number
US06576762B2

Reaction notes

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