HCID 10120092, compound → HCID 10210262, compound

HRID 1369164Notes

Reaction equation

[C:1]([N:4]([CH3:39])[C:5]1[N:10]=[CH:9][C:8]([N:11]([CH3:31])[C:12](=[O:30])[C:13]([C:16]2[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([C:26]([F:29])([F:28])[F:27])[CH:17]=2)([CH3:15])[CH3:14])=[C:7]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[CH3:38])[CH:6]=1)(=[O:3])[CH3:2].F[C:41](F)(F)[C:42]1C=C(C(C)(C)C(N(C)C2C(C3C=CC=CC=3C)=CC(NC(C3CC3)=O)=NC=2)=O)C=C(C(F)(F)F)C=1>>[F:24][C:22]([F:25])([F:23])[C:20]1[CH:21]=[C:16]([C:13]([CH3:15])([CH3:14])[C:12]([N:11]([CH3:31])[C:8]2[C:7]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[CH3:38])=[CH:6][C:5]([N:4]([CH3:39])[C:1]([CH:2]3[CH2:42][CH2:41]3)=[O:3])=[N:10][CH:9]=2)=[O:30])[CH:17]=[C:18]([C:26]([F:29])([F:28])[F:27])[CH:19]=1

Participants

Reactant 2

HCID 10120092HCID 10120092, compound

HCID 10209850HCID 10209850, compound

Product 1

HCID 10210262HCID 10210262, compound

Procedure

The title compound was prepared as a white foam in comparable yield according to the procedure described above for the preparation of N-[6-(acetyl-methyl-amino)-4-o-tolyl-pyridin-3-yl]-2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-isobutyramide using cyclopropanecarboxylic acid (5-{[2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl]-methyl-amino}-4-o-tolyl-pyridin-2-yl)-amide instead of N-(6-acetylamino-4-o-tolyl-pyridin-3-yl)-2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-isobutyramide.

Workup

customin comparable yield

Sources & evidence

ORD record: ord-4c34f56851084c8fa55449623ca5f7db
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06576762B2

Reaction notes

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