HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Cyanophenylboronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| Reactant | 4-Formylphenylboronic Acid | HCID 591073 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Cyanophenylboronic acid | HCID 2734326 | 144.1% |
Reaction Steps
17 g (100 mmol) of hydroxylamine sulfate were added at 70° C. to 15 g (100 mmol) of 4-formylphenylboronic acid, 10 g of water, 5 g (60 mmol) of pyridine and 200 ml of toluene. The mixture was then refluxed on a water separator. When all the water had been removed, the pyridinium salts were separated off, giving 12.7 g (87%) of 4-cyanophenylboronic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576789B1 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-e35822cf005646279ebdb67b4f90ad0a |
| Source note | uspto-grants-2003_06 |