Butanedione → HCID 178465752, compound

Participants

Reaction Steps

A mixture of 0.3 mol of cis-decalin, 1.8 mol of biacetyl, 30 mmol of N-hydroxyphthalimide, 1.5 mmol of cobalt(II) acetate, and 300 ml of acetic acid was stirred at 60° C. in an oxygen atmosphere at atmospheric pressure for 4 hours. The reaction mixture was concentrated to about 20% by weight, and was extracted with ethyl acetate, and the extract was concentrated and was then subjected to column chromatography on a silica gel to yield 4a-acetyl-cis-decalin and 4a-acetyl-8a-hydroxy-cis-decalin.

Provenance & Evidence