HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (+/-)-10,11 dihydro-3-methoxy-5H-dibenzo[a,d]cycloheptene-10-acetate → Ethyl (+/-)-10,11-dihydro-7-fluoro-3-hydroxy-5H-dibenzo[a,d]cycloheptene-10-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (+/-)-10,11 dihydro-3-methoxy-5H-dibenzo[a,d]cycloheptene-10-acetate | HCID 15462070 | — |
| Reactant | Ethyl (+/-)-10,11-dihydro-7-fluoro-3-methoxy-5H-dibenzo[a,d]cycloheptene-10-acetate | HCID 54358299 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | Ethyl (+/-)-10,11-dihydro-7-fluoro-3-hydroxy-5H-dibenzo[a,d]cycloheptene-10-acetate | HCID 53640576 | — |
Reaction Steps
According to the procedure of Preparation 10 (g), except substituting ethyl (±)-10,11-dihydro-7-fluoro3-methoxy-5H-dibenzo[a,d]cycloheptene-10-acetate for the ethyl (±)-10,11-dihydro-3-methoxy-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was obtained as a white solid following silica gel chromatography (1% MeOH/CH2Cl2): MS (ES) m/e 315.0 (M+H)+, 332.0 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06576643B2 |
| Source dataset | uspto-grants-2003_06 |
| ORD ID | ord-97cc08c989434f95932444f1ad49e4a1 |
| Source note | uspto-grants-2003_06 |