Water → HCID 18518328, compound

Participants

Reaction Steps

To a solution of 2-(4-methoxy-2-phenoxyphenyl)-1-morpholin-4-ylethan-1-thione (0.35 g, 1.02 mmole) in i-PrOH (15 mL) and H2O (15 mL) was added KOH (0.57 g, 10.2 mmole). The reaction was heated at reflux for 18 hr, then was cooled to RT, diluted with H2O, and washed with Et2O. The aqueous layer was acidified to pH≈4 with conc. HCl and was extracted with CHCl3. The combined extracts were dried over MgSO4 and concentrated to give the title compound (0.22 g) as a white solid. This was used without further purification: MS (ES) m/e 259.0 (M+H)+.

Provenance & Evidence