Lithium Hydroxide → HCID 86585474, compound

Participants

Reaction Steps

A mixture of ethyl (±)-10,11-dihydro-3-[4-(pyridin-2-ylamino)-1-butyl]-5H-dibenzo[a,d]cycloheptene-10-acetate (46 mg, 0.11 mmole) and 1.0 N LiOH (0.66 mL, 0.66 mmole) in THF (3 mL) and H2O (3 mL) was stirred at RT. After 24 hr, the reaction mixture was concentrated on the rotavap, and the residue was diluted with H2O (5 mL). The solution was cooled in an ice bath, and 1.0 N AcOH was added slowly to give a white precipitate. Chromatography on C-18 YMC (45% CH3CN/H2O containing 0.1% TFA) gave the title compound (13 mg, 21%) as a white solid: MS (ES) m/e 401.3 (M+H)+. Anal. Calcd for C26H28N2O2.0.75 H2O.1.5 CF3CO2H: C, 59.54; H, 5.31, N, 4.72. Found: C, 59.69; H, 5.31; N, 4.72.

Provenance & Evidence