Tetrahydrofuran → HCID 18518357, compound

Participants

Reaction Steps

A solution of ethyl (±)-10,11-dihydro-3-[3-(3,4,5,6-tetrahydropyrimid-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate (0.17 g, 0.36 mmol), lithium hydroxide monohydrate (0.042 g, 1 mmol), THF (3 mL), and water (10 mL) was stirred at room temperature for 20 hr, then was concentrated. The residue was dissolved in water, and the solution was brought to pH 4 with 3 N HCl. The resulting solution was kept in the refrigerator overnight, then the supernatant was decanted away from the solid. The solid was dried in vacuum to give the title compound (0.145 g, 91%) as a tan solid: MS (ES) 408.3 (M+H)+. Anal. Calcd for C24H29N3O3.1.3 HCl: C, 63.37; H,6.71; N, 9.23. Found: C, 63.67; H, 6.84; N, 9.46.

Provenance & Evidence