HCID 12071478, compound → HCID 18518303, compound

Participants

Reaction Steps

Saponification was conducted according to the procedure of Example 6 (c), except substituting ethyl (±)-10,11-dihydro-2-(dimethylamino)methyl-7-fluoro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate for the ethyl (R)-10,11-dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate. The reaction was acidified with glacial HOAc, and the crude product was desalted by chromatography on XAD-2 resin to afford the title compound as a white solid: MS (ES) m/e 478.3 (M+H)+. Anal. Calcd for C30H36FN3O5.1.25 H2O: C, 64.32; H, 6.92; N, 7.50. Found: C, 63.87; H, 6.47: N, 7.96.

Provenance & Evidence