Sodium Hydroxide → HCID 11742647, compound

Participants

Reaction Steps

A mixture of ethyl (S)-10,11-dihydro-3-[3-(4-methylpyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate (2.08 g, 4.69 mmole) and 1.0 N NaOH (7.0 ml, 7.0 mmole) in absolute EtOH (45 mL) was warmed in an oil bath set at 45° C. After 18 hr, the reaction was concentrated on the rotavap and the pH was adjusted to 7 with 1.0 N HCl. The solid precipitate was collected and washed with H2O. Drying overnight afforded the title compound (1.61 g, 82%) as a nearly colorless solid: MS (ES) m/e 417.4 (M+H)+. Anal. Calcd for C26H28N2O3.1.0 H2O: C, 71.87; H, 6.96; N, 6.45. Found: C, 71.63; H, 6.96; N, 6.30.

Provenance & Evidence