HCID 54315823, compound → HCID 20592593, compound

HRID 1369253Notes

Reaction equation

[CH3:1][CH:2]([O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([NH:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]3[CH2:25][C@@H:24]([CH2:26][C:27]([O:29]C(C)C)=[O:28])[C:23]4[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=4[CH2:21][C:20]=3[CH:37]=2)[CH:6]=1)[CH3:3].CC1C=CN=C(NCCCOC2C=CC3C[C@@H](CC(OCC)=O)C4C=CC=CC=4CC=3C=2)C=1>>[CH3:3][CH:2]([O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([NH:11][CH2:12][CH2:13][CH2:14][O:15][C:16]2[CH:17]=[CH:18][C:19]3[CH2:25][C@@H:24]([CH2:26][C:27]([OH:29])=[O:28])[C:23]4[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=4[CH2:21][C:20]=3[CH:37]=2)[CH:6]=1)[CH3:1]

Participants

Reactant 2

HCID 54315823HCID 54315823, compound

HCID 86585477HCID 86585477, compound

Product 1

HCID 20592593HCID 20592593, compound

Procedure

According to the procedure of Example 13 (c), except substituting isopropyl (S)-10,11-dihydro-3-[3-[4-(2-propyloxy)pyridin-2-ylamino]-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate for the ethyl (S)-10,11-dihydro-3-[3-(4-methylpyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was obtained as white powder: MS (ES) 461.3 (M+H)+. Anal. Calcd for C28H32N2O4.0.96 HCl: C, 67.86; H, 6.70; N, 5.65. Found: C, 68.26; H, 6.86; N, 5.25.

Sources & evidence

ORD record: ord-cee91ac94f8848db9c52d348462272ed
Source dataset: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06576643B2

Reaction notes

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