HCID 54176536, compound → HCID 20592611, compound

HRID 1369254Notes

Reaction equation

HRID 1369254 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[CH:15][C:16]3[CH2:22][C@@H:21]([CH2:23][C:24]([O:26]CC)=[O:25])[C:20]4[CH:29]=[CH:30][CH:31]=[CH:32][C:19]=4[CH2:18][C:17]=3[CH:33]=2)[CH:3]=1.CC1C=CN=C(NCCCOC2C=CC3C[C@@H](CC(OCC)=O)C4C=CC=CC=4CC=3C=2)C=1>>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:14]=[CH:15][C:16]3[CH2:22][C@@H:21]([CH2:23][C:24]([OH:26])=[O:25])[C:20]4[CH:29]=[CH:30][CH:31]=[CH:32][C:19]=4[CH2:18][C:17]=3[CH:33]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 54176536HCID 54176536, compoundHCID 54315823HCID 54315823, compound

Product 1

HCID 20592611HCID 20592611, compound

Procedure

According to the procedure of Example 13 (c), except substituting ethyl (S)-10,11-dihydro-3-[3-(4-chloropyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate for the ethyl (S)-10,11-dihydro-3-[3-(4-methylpyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was obtained as off-white powder: MS (ES) 437.2 (M+H)+. Anal. Calcd for C25H25N2O3.1.0 HCl: C, 63.43;. H, 5.54; N, 5.92. Found: C, 63.11; H, 5.82; N, 5.62.

Sources & evidence

ORD record
ord-db419e710c7d40df9d19b866eaa987f4
Source dataset
uspto-grants-2003_06
Patent number
US06576643B2

Reaction notes

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