HCID 12071478, compound → HCID 18518252, compound

HRID 1369257Notes

Reaction equation

HRID 1369257 reaction equation
[F:1][C:2]1[CH:33]=[CH:32][C:5]2[CH:6]([CH2:26][C:27]([O:29]CC)=[O:28])[CH2:7][C:8]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=4)=[CH:11][C:9]=3[CH2:10][C:4]=2[CH:3]=1.N1C=CC=CC=1NCCCOC1C=CC2C[C@H](CC(OCC)=O)C3C=CC=CC=3CC=2C=1>>[F:1][C:2]1[CH:33]=[CH:32][C:5]2[CH:6]([CH2:26][C:27]([OH:29])=[O:28])[CH2:7][C:8]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=4)=[CH:11][C:9]=3[CH2:10][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 12071478HCID 12071478, compoundHCID 86585479HCID 86585479, compound

Product 1

HCID 18518252HCID 18518252, compound

Procedure

According to the procedure of Example 6 (c), except substituting ethyl (±)-10,11-dihydro-7-fluoro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10 -acetate for the ethyl (R)-10,11-dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetate, the title compound was obtained: MS (ES) m/e 421.1 (M+H)+. Anal. Calcd for C25H25FN2O3.0.5 H2O: C, 69.99; H, 6.10; N, 6.52. Found: C, 69.86; H, 5.90; N, 6.35.

Sources & evidence

ORD record
ord-3584a8a2c4cf45b593f9573571ea5675
Source dataset
uspto-grants-2003_06
Patent number
US06576643B2

Reaction notes

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