4-Methylmorpholine → HCID 53957133, compound

Participants

Reaction Conditions

Reaction Steps

To 2-Acetylamino-3-(3-bromo-4-hydroxy-phenyl)-propionic acid methyl ester (3 g, 9 mmol), diethyl phosphite (1.6 ml, 11 mmol) and 4-methylmorpholine (1.5 mL, 13.5 mmol) in toluene (10 mL) and MeCN (10 mL) was added Pd(Ph3)4 (0.5 g, 0.45 mmol). The mixture was allowed to stir for two days at 100° C. It was then diluted with saturated NH4Cl and extracted with EtOAc. The organic layer was dried over magnesium sulfate, concentrated , and chromatographed over silica gel (5% MeOH/CHCl3) to an oil. MS [M+H]+ 374 and [M−H]− 372.

Provenance & Evidence