Lithium hydroxide, monohydrate → HCID 18519020, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-[3,4-Bis-(diethoxy-phosphoryl)-phenyl]-2-tert-butoxycarbonylamino-propionic acid methyl ester (110 mg, 0.2 mmol) in 5 mL of THF cooled to 0° C. was added dropwise a solution of lithium hydroxide monohydrate (8.5 mg, 0.2 mmol) in 1.0 mL of water. The reaction mixture was stirred at 0° C. for 1 h. THF was removed under reduced pressure to a yellow oil which was diluted with 10 mL of 1 N HCl. The aqueous phase was extracted with CH2Cl2 (2×15 mL), and the extracts were combined, dried over Na2SO4, and concentrated to afford an oil 107 mg (100%). MS [M−H]− 537.

Provenance & Evidence