Water → HCID 53895791, compound

Participants

Reaction Steps

3-(3-Diethoxyphosphoryl-4-vinyl-phenyl)propionic acid methyl ester (200 mg, 0.61 mmol) was dissolved in 3.9 mL CCl4 and 3.9 mL of MeCN. NaIO4 (388 mg, 1.81 mmol) was dissolved in 6 mL H2O and was added. The mixture was stirred vigorously and RuCl3 (10 mg, 0.05 mmol) was then added and the mixture was stirred for 1 hr at rt The reaction was diluted with DCM, organic layer was separated, dried Na2SO4 and concentrated. The residue was purified by flash column chromatography on silica gel (4/1 EtOAc/hexane, Rf=0.37) to give pure product as an oil, 153 mg (yield 76%).

Provenance & Evidence